Vl. Șandor, O. Coza, S.H. Mureșan, Anca Dana Buzoianu *
* Conf. dr. Vlaicu Șandor, Dr. Ovidiu Coz, Dr. Sorin H. Mureșanu, Asist. univ. dr. Anca Dana Buzoianu, Catedra de Farmacologie și Toxicologie, U.M.F. “Iuliu Hațieganu” Cluj-Napoca
Article information. Original Paper · Ther Pharmacol Clin Toxicol 1997;1(2):38–42 · Article in Romanian with an English abstract
Abstract
The potential antihypoxic effect of piracetam has been evaluated on a reproducible model of hypoxic hypoxia in guinea pigs. Installing a transientperiod of apneea, visible cerebral and cardiac pathological changes occur on EEG and ECG. Piracetam in a 0,25 mmoles/kg unique dose facilitated the pos th ypo xic neuro nal recovery. The superior 4 nimoles/kg dose, delays the onset of the pathological modifications on the EEG and it accelerates, as well as the inferior dose, the reinitiation of the electric cerebral activity. Piracetam, in both doses, failed to protect the myocardium against hypoxic hypoxia.
Keywords: nootropic drugs piracetam hypoxic hypoxia cardiac arrhythmias
Cite as: Șandor V, Coza O, Mureșan SH, Buzoianu AD. Efectul piracetamului asupra modificărilor cerebrale și cardiace induse de hipoxia prin apnee tranzitorie. Ther Pharmacol Clin Toxicol. 1997;1(2):38–42.
