V. Cârlig *, A. Tica *, C. Georgescu *
* Conf. dr. V. Cârlig, Dr. A. Tica, Dr. C. Georgescu – Catedra de Farmacologie, Facultatea de Medicină Craiova
Abstract
The capacity of tricyclic antidepresives to lower the cholinergic reactivity is generally accepted.In the present work it is demonstrated that the interaction between tricyclic antidepresives-cholinergic system has a biphasic evolution: low concentrations enhance acetylcholinic response and only high concentrations fits with the concen trations fits with the concept of “anficholinergic effect’’. We suggest that the effects of tricyclic antidepresives at the molecular level may be the result of a “membrane stabilization” mechanism, so that the low concentrations amplify the cholinergic response of the preparation, due to the rise of his compliance, the subsequent cholinergic effect being the consequence of the relaxant action of the high concentrations, which diminish the cholinergic reactivity.