Dana Goşa 1, Anca Dana Buzoianu 2, Ruxandra Schiotis 1, Ş. Vlaicu 1, Corina Neculiţă 2
1 Department of Pharmacology and Toxicology „Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca
2 Department of Clinical Pharmacology „Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca
Abstract
Introduction. The ionic mechanism that stands at the base of the central arrhythmias it is not known exactly yet. The current researches at the UMF Cluj-Napoca, Department of Pharmacology and Toxicology showed that there are substances which could cause changes of cardiac rhythm and cardiac frequency when were administrated by microinjections into the cerebral lateral ventricle of rats in narcosis. In this study we examined the effects of aluminium chloride on central cardiac arrhythmia using pharmacological means. Material and methods. We used for the study Wistar white rats, with weight between 130-180 grams, in narcosis produced by ethylurethane. Results. We obtained central caused cardiac arrhythmias by giving aluminium chloride into the cerebral lateral ventricle. Conclusion Aluminium chloride is not a protective agent against the arrhythmic effect of sodium glutamate which is known as the reference arrhythmic substance.