Raluca Dumache 1, Marinela Popovici 2, B. Bumbăcilă 3, Maria Puiu 4
1 Department of Biochemistry, University of Medicine and Pharmacy “Victor Babeş’’, Timişoara, Romania
2 Department of Pharmacology, University of Medicine and Pharmacy “Victor Babeş’’, Timişoara, Romania
3 Faculty of Pharmacy, Department of Clinical Pharmacy, University of Medicine and Pharmacy “Victor Babeş’’, Timişoara, Romania
4 Department of Medical Genetics, University of Medicine and Pharmacy “Victor Babeş’’, Timişoara, Romania
Abstract
Genetic constitution represents an important cause for individual variations in the response and tolerance to drug treatment. Th ese variations are due to the germline mutations in genes that encode for drug-metabolizing enzymes, transporters, cellular targets and signaling pathways. The identifi cation of genetic variations that predict for drug response is an important step towards the translation of pharmacogenetics into clinical practice. The knowledge of pharmacogenetics can aid in the discovery, development and individualization of anticancer drugs.