V. Tica 1, O. Teren 2, A.A. Tica 3, Irina Tica 4, P. Mareș 5, C. Gouzes 6, P. Badea 7, O. Unc 8
1 V. Tica – Medic Primar, șef Lucrări Obstetrică-Ginecologie, Șel de Secție Facultatea de Medicină Constanța
2 O. Teren – Șef Lucrări Facultatea de Medicină Constanța, Disciplina Informatică Medicală
3 A.A. Tica – Șef Lucrări UMF Craiova, Disciplina Farmacologie, Medic Primar Obstetrică-Ginecologie
4 Irina Tica – Facultatea de Medicinii Constanta
5 P. Mareș – Profesor, Șef Clinică Obstetrică-Ginecoloie, Facultatea de Medicină Montpellier-Nîmes, Franța
6 C. Gauzes – Facultatea de Medicină Montpellier-Nîmse, Departamentul de Informatică Medicală, Franța
7 P. Badea – Șef Lucrări UMF Craiova, Disciplina de Informatică Medicală
8 O. Unc – Medic Primar Chirurg, Șef Lucrări Facultatea de Medicină Constanța
Abstract
This work aims to determine the necessary number of determinations for obtaining significant statistical results concerning total and conjugated bilirubin variation during ovarian stimulation for in vitro fertilization. For 23 stimulation cycles, in 25 – 47 years old infertile patients, included in a IVF program – GnRH agonists/hMG/ hCG, long protocol – in0 8/GYN Department, University H ospi tal , Nîmes, France , we determined total and conjugated bilirubin before beginning the protocol, the day of beginning of hMG, the days 22, 24, the day before triggering ovulation, the day of oocyte retrieval, 15 days after the embryo transfer and the next month . Statistics were performed in Medical Computing Departments in Constanta, Craiova and Montpellier, France (Digital Vax Computer, soft BMDP and SAS 6.0). The values that we obtained calculate the number of necessary determinations for asserting a significant difference at 37 – 51 for total bilirubin (38 for a 5% difference) and 29 – 37 for conjugated bilirubin (25 for a 5% difference). The suppositions considered in our study offer a correct estimation of the magnitude of the following research group.