Corina Itu 1, C. Jianu 1, Doina Tăţulescu 2, Mirela Flonta 1, Ligia Ursu 1, Virginia Zanc 2, D. Cârstina 1
1 Spitalul Clinic de Boli Infecţioase, Cluj-Napoca
2 UMF ,,Iuliu Haţieganu”, Cluj-Napoca
Abstract
Background: mitochondrial toxicity is an adverse event of nucleoside reverstranscriptase inhibitors. The biochemical marker is the increased level of serum lactate. Objectives: to identify the risk factors for hyperlactatemia and to establish a prognostic score. Methods: we prospectively studied 49 adults under ART. Lactate level and other parameters were studied. Univariate and multivariate statistics were used. Results: risk factors for hyperlactatemia are: age over 40 and hemoglobin under 11g%. The result of prognostic score was 0.5. Conclusions: a good prognosis means a score under 0.5. The score might be a replacement method for the lactate concentration.