Cristina Popescu, Victoria Aramă, Adriana Hristea, Adriana Paise, Daniela Munteanu, C. Tilişcan, Ruxandra Moroti, M. Chiotan, Raluca Năstase, Violeta Molagic, Mihaela Rădulescu, Daniela Nicolae, Raluca Mihăilescu, Rodica Bacruban
Institutul Naţional de Boli Infecţioase “Prof. Dr. Matei Balş”, Bucureşti
Abstract
We made a prospective descriptive study about viral meningitis like a reaction to epidemiological alert from June 2007 in Romania. Objective: to analyze the cases of meningitis in order to identify a possible etiological agent. Methods: we excluded the cases of pyogenes and tuberculosis meningitis. We analyzed 28 cases of meningitis with a case definition: meningian syndrome with more than 7 nucleate cells/mmc. Results: mean age 23,8 years (between 14 and 38 years), the predominance of male, equivalent distribution regarding rural vs urban provenience and water distribution. Clinic: were moderate cases, without encephalitis syndrome, with moderate meningeal syndrome in 46% of cases. In 4 cases we observed lymphatic nods inflammation, 12 patients associated sinusitis, 16 patients had moderate increased level of fibrinemia and 4 patients had more than 12000 leucocytes/mmc. CSF examination showed: in 23 cases below 250 cells/mmc and 8 patients below 100cells/mmc. The CSF glucose was normal in 25 patients, 3 patients had moderate increase of CSF glucose. CSF protein was increased but the value was below 200 mg% for all patients (below 100 mg% for 22 patients). For five patients we identified echo4 virus in CSF and for 2 cases we identified serum antibody for adenovirus. All the patients received pathogenic and symptomatic medication. 22 patients received for more than 24 hours antimicrobial therapy, the most frequent, Ceftriaxone. Conclusions: 2007 viral meningitis epidemia affected young people, male, and outcome was favorable in all the cases.