Andrea Incze 1, Carmen Lucia Chiriac 1, Iringo Zaharia Kezdi 1
1 University of Medicine and Pharmacy, 1st Clinic of Infectious Diseases Tg. Mures
Abstract
Treatment experienced patients had limited treatment options during the past decade. The situation has changed with the arrival of the new antiretrovirals. We describe the case of a human immunodeficiency virus (HIV) infected patient with previous therapeutic failures, low levels of T CD4+ cell count and high viral load, three-drug class resistant virus. Undetectable viral load lasting for more than 80 weeks has been obtained using a regimen containing three fully active antiretrovirals: raltegravir, darunavir and enfuvirtide. Lamivudine was associated to this regimen, to reduce viral fitness. This combination conducted to favourable clinical, immunological and virological outcome. These new antiretrovirals offer new hope to treatment experienced patients in a way that could not have been possible before. Keywords: