Maria Magdalena Pastramagiu 1, O. C. Mungiu 1
1 Centre for Pain Study and Therapy “Gr. T. Popa” University of Medicine and Pharmacy, Iaşi
Abstract
The aim of this study is the experimental research of the influence of Ketonal and combination of Ketonal and Enap on nociception in naïve and ethanol treated rats. Materials and methods: We used male Wistar rats divided in two groups: naïve rats and ethanol treated rats (10% solution of alcohol, for three weeks). Both groups received intraperitoneal Ketonal 1 mg/kbw, and Ketonal (the same dose) in combination with Enap (20 μg/kbw). The control group received distilled water. Nociception was investigated through the hot plate assay, at 15, 30, 60, 90 minutes after the administration of substances. The results were statistically analyzed using the Anova test, followed by the post-hoc test. In conclusion, we have found Ketonal antinociceptive effect, both in naïve and in ethanol treated rats, more evident in the first case. The association of Ketonal with Enap produced analgesia in naïve animals and nociception in the case of alcohol fed rats.