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Implications of the imidazoline system in the human brain

March 31, 2025
The imidazoline system is formed by the imidazoline receptors I1, I2 and I3 and the natural competitive agonists that have been identified in the human and animal body: agmatine, harman, harmalan and imidazole-4-acetic acid-ribotide. I1 and I3 receptors are located in the cell membrane.
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Implementing next-generation sequencing for personalized pharmacotherapy decisions

March 31, 2025
Personalized pharmacotherapy harnesses patient-specific information—especially genetic data—to tailor drug se-lection and dosing for optimal safety and efficacy. Next-generation sequencing (NGS) technologies have revolu-tionized the ability to interrogate the genome, uncovering both common polymorphisms and rare variants that influence drug response. This narrative review discusses the theoretical foundations of pharmacogenomics as en-abled by NGS, highlights emerging
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