Madelena Drăgan *, Gh. Jugulete *, Ana-Maria Tudor *, Dorina Duma **, E. Gheorghe **, Mariana Mărdărescu **, R. Măntescu **, C. Petre **, S. Petrea **
* Prof. dr. Madelena Drăgan, dr. Gh. Jugulete, preparator, dr. Ana-Maria Tudor, asist. univ. U.M.F
“Carol Davila” București – Clinica de Boli lnfecțioase III – Pediatrie
** Dr. Dorina Duma, dr. E. Gheorghe, dr. Mariana Mărdărescu, dr. R. Măntescu, dr. C. Petre, dr.
Sorin Petrea, medici primari, Institutul de Boli lnfecțioase “Prof. dr. Matei Balș” București
Abstract
The tolerance and efficacy of antiretroviral therapy in HIV infected children
In this study we have estimated the efficacy and tolerance of antiretroviral therapy in HIV-infected children. We have monitorised clinical and laboratory 2 lots of HIV infected childern, which are trated with antiretroviral drugs, with ages between 9-14 years old, for 12 monts. The first lot of 18 children was treated with two reverse transcriptase nucleosidic inhibitor (NRTl’s – Zidovudine, Didanosine, Lamivudine, Stavudine) and one reverse transcriptase non-nucleosidic inhibitor (NNRTI-Efavirenz). The second lot of 42 HIV infected children was treated with 2 NRTl’s and one protease inhibitor (Pl-indinavir, ritonavir, nelfinavir). Clinical, we monitorised weight and height, adverse experiences and opportunistic infections. Laboratory Findings: CD4 • cell counts, plasma HIV-RNA level and biochemical parameters. Over 90% of patients survived, SHIV-infected children stage C3 died. At months 12- of therapy, the courve of weight and increased. The most common adverse.experiences were nausea, fatigue, headache, diarrhoea, rash, dizzines, vomiting. Clinical opportunistic infections were rare. Were have observed appearance of minor lipodystrophy sings at lot trated with Pl. Mean CD4-cell count increased by approximately 97 cells/mm3 and virus levels were reduced to belox 400 copies/ml in 80% of children treated with treeterapy. Laboratory findings were discretly modified. Antiretroviral therapy was generally well tolerated for the duration of 12-month treatment. Three· terapie brings one categorically benefit for HIV infected children survival duration and quality of live.