Delia Cinteză *, Maria Cristina Constantinescu **
* Dr. Delia Cinteză, asistent universitar, Catedra de Recuperare Medicală și Balneofizioterapie
** Dr. Maria Cristina Constantinescu, asistent universitar, Catedra de Farmacologie – Facultatea de Medicină, U.M.F. “Carol Davila”, București
Abstract
Botulinum toxin A exerts its paralytic action within a few hours by inhibition of acetylcholine release in the synaptic cleft. Chemical denervation with botulinum toxin is considered the first choice treatment for blepharospasm, cervical dystonia, laryngeal dystonia, certain task-specific dystonias and hemifacial spasm. Motor dysfunction due to abnormally increased muscle tone – spasticity – may also be improved by botulinum toxin. The history of hypersensitivity to the toxin and infection at the site of injection are the only absolute contraindications to botulinum toxin.