Adriana Hristea *, Daniela Nae **, Victoria Aramă *, A. Streinu-Cercel ***
* Adriana Hristea, Victoria Aramă – medic primar boli infecțioase, doctor în științe medicale, șef de lucrări – lnstitutul de Boli lnfecțioase “Prof Dr. Matei Balș”, U.M.F “Carol Davila”, București
** Daniela Nae – Medic rezident boli infecțioase, lnstitutul de Boli lnfecțioase “Prof Dr. Matei Balș”
*** Adrian Streinu-Cercel, șef lucrări UMF “Carol Davila”, medic primar șef secție Institutul de Boli lnfecțioase “Prof. dr. Matei Balș”, București
Abstract
Excessive and inappropriate antimicrobial use results in strong selective pressure that facilitates the emergence of antimicrobial-resistant pathogens. The incidence of infec tions caused by antibiotic resistant gram negative bacilli is increasing worldwide, especially in hospital acquired infections, and infections caused by resistant bacteria are associated with increased costs, morbidity and mor tality. Carbapenem antibiotics are considered the agents of choice to treat serious infections caused by enteric pathogens carrying extended-spectrum betalactamases. If carbapenem usage becomes widespread, two bacteria are at risk to emerge as significant nosocomial pathogens carbapenem-resistant Pseudomonas aeruginosa and Aci netobacter baumannii. The increased prevalence of these strains in some area has revived interest in the use of colistin as an antibiotic.