L. Negruţiu
Prof. Univ Dr. – Universitatea de Medicină şi Farmacie “Victor Babeş” Timişoara
Abstract
Recent developments in the pharmacogenomics of antiretroviral drugs provide new prospects for predicting the efficacy of antiretroviral therapy and potential adverse effects. Antiretroviral therapy is especially suitable for pharmacogenomic investigation as both drug exposure and treatment response can be quantified and certain adverse effects can be assessed with validated measures. Additionally, there is increasing knowledge of the pharmacokinetics and dynamics of antiretroviral drugs, and some candidate genes implicated in the metabolism, transport and adverse effects have been identified. This article reviews the recently published work and summarizes the state of research in this area.