V. Benea *, Elisabeta Otilia Benea **
* Dr. Vasile Benea – medic primar dermatolog, Spitalul clinic de Dermatologie “Scarlat Longhin”, București
** Dr. Elisabeta Otilia Benea, medic primar boli infecțioase, șef de lucrări, Clinica I de boli
infecțioase “Colentina”, UMF, “Carol Davila”, București
Abstract
Acne is the most common skin disease, affecting nearly 80% of persons at some time between the ages of 11 and 30 years. Although in most cases is a self-limited disease, it can persist for years and results in permanent scarring and it can have serious adverse effects on psychosocial development. The pathogenesis of acne is multifactorial. The rational treatment must be directed toward the mean factors implicated in acne: the excessive sebum production, the altered pattern of follicular keratinization, and the proliferation of P. acnes. New information about the pathophysiology of acne has led to the development of new drugs that are effective in most patients, sot that there is no reason to wait for spontaneous remission. Combination of topical and/or systemic drugs results in the control of all forms of this disease, even in the most inflammatory and destructive variants. Therapy should be against the several causes of acne. In most patients, a combination of drugs correcting abnormal desquamation and reducing the proliferation of P. acnes is sufficient to control acne. For more severely affected patients with no response to this approach, therapy to suppress sebum production is indicated.