Delia Cinteză *, Maria Cristina Constantinescu **
* Delia Cinteză – Asistent universitar, Catedra de Recuperare Medicală și Balneofizioterapie, UMF Carol Davila
** Maria Cristina Constantinescu – Asistent universitar, Catedra de Farmacologie, UMF Carol Davila
Abstract
Bisphosphonates are analogues of pyrophosphate that inhibit osteoclast-mediated bone resorbtion by mechanisms that are not fully understood. They are very efficient to treat osteoporosis, but the researches for the last five years demonstrate the anti-osteolytic effect in patients with cancer and bone metastases through multiple mechanisms: direct (apoptosis of osteoclasts and tumor cells) and indirect (changes in the bone microenvironment in which the tumor cells grow).