EVALUATION OF THE MOOD-STABILIZERS ASSOCIATEDNEUROCOGNITIVE EFFECTS IN BIPOLAR PATIENTS

December 1, 2011

Vasile D. 1, Vasiliu O. 2, Mangalagiu A. G. 2, Ojog Diana Gabriela 1
1 University of Medicine and Pharmacy “Carol Davila,” Bucharest
2 Military Emergency Universitary Hospital “Dr. Carol Davila” Bucharest, Department of Psychiatry

Abstract

Cognitive impairments in domains like attention, verbal memory, verbal learning and executive function are now considered a feature of bipolar disorder, due to their persistence during the remission periods. Beside that fact, in bipolar patients there are cognitive dysfunctions induced by mood-stabilizers, which are the first line drugs used in this specific pathology. The evaluation of memory and attention functioning, motor speed reaction, associative productivity and creativity represents a necessary step for the monitoring of bipolar patient, because of the anticonvulsants impact over these cognitive variables. The functional prognosis, bipolar patient ability to cope with professional and social duties, as well as his quality of life depend, in a significant proportion, upon monitoring symptoms and decreasing the factors associated with a negative impact on cognitive functions.

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