Manuela Arbunei 1, Voichita Mogoș 2, E. Zbranca 2, Cristina Cristea 2, M. Huțanu 3
1 Spitalul de Boli Infecțioase Galați
2 Clinica de Endocrinologie – UMF Iași
3 Spitalul de Urgență Galați
Abstract
The present study evaluates the development of lipodystrophy syndrome (LDS) during 3 years, to 148 HIV infected children between 11 and 16 years old. They were treated with more antiretroviral (ARV) combinations. LDS was not found to any child under age 12, but has been developed by 41.5% children on media age of 14. 7. 89% of LDS patients have experienced the puberty onset, but there is no correlation with a certain pubertal stage. The dyslipidemia is more frequent than LDS and they both are correlated with certain ARV. The severe baseline immunosupression and the eficiency of immune reconstruction after ARY are associated with LDS. Goiter was found to 62.5% pat ients with LDS but it is not clear either it is favoured by LDS or the goiter and LDS are independent manifestations of the immune reconstruction.