Mariana Rădoi
Prof. univ. dr., Facultatea de Medicină, Universitatea Transilvania Brașov
Abstract
Statins are the most usefull drugs in the treatment of atherogenic dislipi demia. The benefit of statins was demonstrated in primary and secondary prevention of cardiovascular disease and consists in reduction of major cardiovascular events. The clinical benefit is associated with decreasing in LDL-c levels. New data seems to be needed to establish optimal LDL-c levels in secondary prevention. The benefit is greater and with cost-efficiency in high cardiovascular risk patients. When used in moder ate dosage statins are well tolerated drugs but high statins therapeutic regimen is associated with enhanced risk in increasing of liver enzymes levels.