M. Tudosie *, Ilenuța Dănescu *, Cristina Teodorescu **, R. Macovei *, L. Miclea *, Genica Caragea *
* M. Tudosie, Ilenuța Dănescu, R. Macovei, L. Miclea, Genica Caragea – U.M.F. “Carol Davila” București, Catedra de Toxicologie și Farmacologie Clinică
** Cristina Teodorescu – Spitalul Clinic de Urgență Floreacsa – Clinica de Cardiologie
Abstract
Antidepressants compounds were introduced in depression therapy until ‘50 years, being one important step in development of psychopharmacology. Classified in 5 generations, antidepressants have various structures and action mechanisms. The toxicodynamic mechanisms in acute antidepressants overdose are the blockade of alfa adrenergic receptors, central and peripheral muscarinic receptors, H₁ si H₂ histaminic receptors. The cardiac toxicity is due by the inhibition of myocardic sodium channels with anticronotropic, antiinotropic and antidromotropic effects, modifying the cardiac frequency and rhythm, intracardiac conduction, myocardial contractility and blood pressure. Cardiovasculary toxic effects occur in plasmatic concentration over 1000 ng/ml. The cardiotoxic ity, consequence of combination of several toxicodynamic effects, is aggravated by metabolic acidosis. The control of acidosis represent the basic therapeutic measure in the acute antidepressants poisoning treatment.