V. A. Voicu *, R. Macovei *, M. Ionică *
* Prof. Victor A. Voicu, Dr. Radu Macovei, Dr. Mihai Ionică, Catedra de Toxicologie clinică, Univestitatea de Medicină şi Farmacie “Carol Davila” şi Centrul de Cercetări Ştiinţifice Medico-Militare
Abstract
In the last years plasmapheresis is often used for the elimination of some endogerous or exogenous components involved in critically state of the human body. One of the first condition for therapeutical indication aim to kinetic characteristics of the target compound. Clinical Department of Toxicology was applied the plasmapheresis fore 10 cases of severe acute poisoning (III and IV – degree coma in Reed Scale). All the studies cases have had toxicological certain diagnosis, the toxic substances involved being drugs in association of 2 to 5 compounds. lt was used an Haemonetics Machine PCS plus. For analytical toxicological determinations, it was used a gas chromatograph coupled with a mass-spectrometer GC/MS Varian Saturn 3. The analysis of the obtained results in comparison to similar poisoning treated patients in our clinical department permit the following conclusions: – the use of plasmapheresis permit the more rapidly recover of poisoned patients in grave status; – the period of intensive case to the with applied plasmapheresis procedure was clealy shorted; – although the ingested doses were greatly than lethal doses, all the patients werw recovered without complication. Using plasmapheresis in some severe acute poisoning, with an adequate by preliminary clinical and toxicological evaluation and montoring and all the period of application, end with superior clinical results than other therapeutically known methods.