B. Opriță *, Rodica Mirescu *, C. Pandrea *, M. Iancu **, R. Ciuvică **, I. Enescu **
* Dr. B. Opriță, Dr. Rodica Mirescu, Dr. C. Pandrea – Medici specialiști Medicină de urgență, Departament Urgențe Majore, Spitalul Clinic de Urgență, București
** Dr. M. Iancu, Dr. R. Ciuvică, Dr. I. Enescu – Medici rezidenți Medicină de Urgență, Spitalul Clinic de Urgență, București
Abstract
Emergency medical attitude and intensive care of traumatic comas require a continuous and comprehensive evaluation of the neurologic status. Using advanced monitoring techniques fulfills this requirement. Often, patient sedation is necessary. Decreases in blood pressure and heart rate have been reported after the administration of Propofol. These side effects are potentially deleterious in severe trauma, particularly on patients with head trauma. This study tries to evaluate the effects of propofol (DIPRIVAN, Zenecac) upon sistolic blood pressure, respiratory rate, blood oxygen saturation and the neurologic status, by the Glasgow Coma Scale (GCS) of comatose patients after severe and moderate isolated head trauma. 36 patients with isolated head trauma and GCS < 9 have been haemodynamically and respiratory assesed after they have received Propofol (DIPRIVAN) in continuous infusion, in an average dosage of 4,3 mg/Kg/h – the study group. We have compared the results with similar findings on a group of 30 patients with isolated head trauma and GCS < 9 that haven’t been sedated with Propofol (DIPRIVAN) – the control group. No significant differences have been observed. Conclusion: In a controlled, randomized study, we have demonstrated that propofol (DIPRIVAN) seems to be safe when used for the prolonged sedation of a homogenous group of head trauma patients.