Adina M. Dobriţoiu 1, D. G. Forsea 2
1 “Carol Davila” University of Medicine and Pharmacy, Bucharest
2 Dermatology Department, Colentina Hospital
Statins and are by far the most widely used class of lipid-lowering drugs and they are the class of choice for LDL-C reduction. Their cutaneous side effects reported in medical literature so far can be classified into four types: autoimmune reactions, reactions due to dryness of the skin, severe reactions like –DRESS, and allergic reactions. Recent research has proven that statins also have immunomodulatory activities and thus they can be used in the treatment of several immunological conditions which are characterized by a Th1 immune response. Statins are reported to be effective against psoriasis, to improve altered wound repair in diabetic skin, to decrease the incidence of skin cancer or to decrease fibroblasts activities in systemic sclerosis. The recently reported beneficial properties need further investigations.