Laura Mihaela Isop 1 *, Ingrid Tanase 1, Andrea Elena Neculau 1, Lorena Dima 1
1 Department of Fundamental, Prophylactic and Clinical Sciences, Faculty of Medicine, Transilvania University of Brașov, Brașov, Romania
*Correspondence to: Laura Mihaela Isop, Department of Fundamental, Prophylactic and Clinical Sciences, Faculty of Medicine, Transilvania University of Brașov, 500036, Brașov, Romania. E-mail: laura.isop@gmail.com
Abstract
Polypharmacy has become a growing public health concern, particularly in aging populations with multimorbidity. Although appropriate polypharmacy can improve clinical results, inappropriate or excessive drug use raises the like-lihood of adverse drug events, medication errors, and lower compliance. Emphasizing suitability, safety, efficacy, and harmony with personal health objectives, Structured Clinical Pharmacology Reviews (SCPRs) provide a methodical, patient-centered approach to maximizing drug regimens. Studies show that SCPRs can find and fix issues with med-ications, increase compliance, lower hospitalizations, and save money. Their effect on quality of life and long-term results, however, stays inconsistent and implementation in general practice confronts systematic, organizational, and individual-level obstacles. Important obstacles are inadequate digital infrastructure, inconsistent training, limited time frames, and low patient involvement. Though integration differs across healthcare systems, facilitators like decision-support tools, electronic health records, and encouraging policy frameworks can improve SCPR delivery. Improving Clinical Pharmacology and Therapeutics (CPT) education is therefore essential for SCPR success. Pre-scribers must be able to safely and effectively assess and control complicated drug regimen. Supporting rational pre-scribing practices requires CPT training in medical curricula and promoting interprofessional cooperation among clinical pharmacologists, pharmacists, and other medical specialties. Ultimately, while SCPRs are a great tool for maximizing polypharmacy management, their efficient use in primary care relies on systematic support, workforce development, and clinical pharmacology education. Coordinated policies, technology, and training can improve prescribing practices and help to make more effective, safer, and patient-centered use of medications.
