V. Cârlig *, V. Voicu **, C. Georgescu *, A. Tica *
* Conj. Dr. V. Cârlig, Dr. C. Georgescu, Dr. A. Tica – Catedra de Farmacologie – Fac. de Medicină Craiova
** Prof. Dr. V. Voicu – Catedra de Toxicologie UMF București
Abstract
At central nervous system level, benzodiazepine-flumazenilinteraction represents a situation of “competitive antagonism”. In periphery, both diazepam and flumazenil depress the cholinergic reactivity in a isolated intestin preparation. Moreover, association of diazepam and flumazenil augments anticholinergic action. Therefore, the antagonic relationship between the two drugs at central nervous system level becomes a synergic one in periphery. Flumazenil, as well diazepam, are benzodiazepines act by a common mechanism. The anticholinergic effect could involve a specific benzodiazepinic receptor, or more likely, alteration of the membrane conductance.