F. Bădulescu *, Adriana Bădulescu **, V. Cârlig **, Veronica Diță *, L. M. Pop *
* Conf. Dr. F. Bădulescu, Adriana Bădulescu, Veronica Diță, Dr. L.M. Pop – Disciplina de Oncologie, Fac. de Medicină – Craiova
** Conf. Dr. Valentin Cârlig – Disciplina de Farmacologie, Fac. de Medicină – Craiova
Abstract
The aim of paper is the assessment of an original study begun in 1985 that has enrolled 70 patients (half of them in premenopausal status and half in postmenopausal status) with breast cancer, stages II and Ill (A+B), followed dinamically; cases in which the ,,classical” therapeutical approach, primary in second stage and secondary in the third stage. The patients’ age was between 28 and 60 years, the most of them overweighted and 35 patients have refused surgery in any moment. The diagnosis was made up by T, N, M elements (UICC 1987). The malignity was established by the histopathological extemporaneum in operated patients and by the fine needle aspiration biopsy with cytological exam or by cytological exam of the ulcerated lesion in stage IIIB. The results have revealed: 1. undifferentiated evolution in the first 2 years of treatment (for operated and unoperated) 2. undifferentiated evolution after 2 years, too, in postmenopausal patients, the unoperated patients were treated by the association of CT+RT (6-12 sequences – CMF or FEC; 5 500 rad for every field) and hormonotherapy with Tamoneprin 20 mg/day, mean 5 years; 3. a differentiated evolution in premenopausal patients , the unoperated showing recurrent after 16-18 months, imposing the repeated of CT and a supliment of dose of radiotherapy. The conclusions of study being: 1. the invasive forms have a differentiated evolution with or without surgery, which favorable in postmenopausal and which has a reccurential potential in premenopausal patients; the moreyoung the female is, the bigger is this; 2. the associations FEC (especially in young female) and CMF, along with hormonotherapy in initial cure stages, that hadn’t undergone surgery as primary approach is correlated with a significant favorable answer along with tolerable side effects and with mammary gland keeping associated with a good psichologic effect; 3. the result of a conservator surgery in our algorithms is a histoprognostic factor, because it is offered the necessary elements for furtther therapy-prevented in this way the possible recurrent and metastasizes (the most involved beeing the bone).