V.A. Voicu *, M.E. Hinescu **, Z. Mărculescu ***, M.R. Periețeanu ***
* Prof Dr. Victor A. Voicu, șeful Catedrei de Toxicologie Clinică, U.M.F. “Carol Davila” – Centrul de cercetări știițifice medico-militare
** Dr. M.E. Hinescu – Catedra de Histologie și Biologie celulara, U.M.F. “Carol Davila” – Centrul de cercetări șființifice medico-militare
*** Cerc. șt. Z. Mărculescu, cerc. șt. M.R. Periețeanu, Centrul de cercetări științifice medico-militare
Abstract
In this third article, we review some of the cellular events, which could intervene in the signal transduction of apoptotic cell death. One of the questions in disscussion is: How a reversible process such as phosphorylation could participate as a facilitator of an irreversible outcome such apoptosis? Further, we examine which are the common features of cell cycle, apoptosis and tumoral progression. Finally, calcium ions and free radicals are examined as triggers (or effectors) involved in certain cell signaling pathways which could promote cell death. All these data are evaluated keeping in mind the possibility that the modulation of apoptosis could be an extraordinary potential target for the design of several classes of very effective new drugs.