V. Cârlig *, V. Voicu **, C. Georgescu *
* Conf. Dr. Victor Cârlig, Asist. Dr. Cristian Georgescu – Disciplina de Farmacologie, Facultatea de Medicină – Craiova
** Prof Dr. Vidor Voicu – Disciplina de Toxicologie U.M.F., București
Abstract
The calcium antagonists comprise a heterogeneous group of agents that have as their primary site of action the voltage-gated calcium channel. These agents can be classified according to several sets of consideration. These consideration include the class or subclass of the voltage-gated calcium channel the site of a channel at witch the drug interacts, and the pathology of the tissue. Mibefradil has a specific profile of calcium influx inhibition via a T-channel. The main pharmacological characteristics of mibefradil are its lack of negative inotropism at therapeuitc concentrations, the absence of cardiac reflexes induced by peripheral vasodilatation, a slight decrease of heart rate, and its failure to cause constipation. Such a characteristics are the reason to select a new drugs, capable to block T-type voltage-operated calcium channels.