Florica Popescu *, F.D. Popescu **, L. N. Ghilencea ***
* Conferenţiar dr. Florica Popescu, Disciplina de Farmacologie, Facultatea de Medicină, Universitatea din Craiova
** Asistent universitar Florin-Dan PoPescu, Disciplina de Alergologie, U.M.F „Carol Davila”, București
*** Liviu Nicolae Ghilencea, Doctorand, Disciplina de Farmacologie, Facultatea de Medicină din Craiova
Abstract
Chronic obstructive pulmonary disease (COPD) is characterised by various abnormalities in the airways and lung parenchyma. Oxygen free radicals play an important role, and one of the major antioxidants mechanisms is the glutation-redox cycle. Antioxidant and antielastase therapy can improve the balances between free radicals/antioxidant systems and elastase/antielastase. N-acetylcysteine has antioxidant effect and alpha-1 antitrypsin present antielastasic action. These strategies may play an important role in the pharmacotherapeutical approach of chronic obstructive pulmonary disease.