Papacocea T. 1, Papacocea R. 2, Bădărău A. 2, Ion A.D. 2, Buraga I. 2, Gaman L. 2, Papacocea A. 3
1 ”St Pantelimon” Emergency Hospital, Neurosurgery Clinic, Bucharest
2 University of Medicine and Pharmacy “Carol Davila,” Bucharest
3 County Hospital Ploiesti, Neurosurgery Clinic
Abstract
Intracerebral hemorrhage (ICH) represents the most lethal form of stroke and has deleterious conequences. Primary injuries are generated by the blood collection itself and consist in local tissue destruction. They are prolonged and amplified by a combination of secondary injuries involving the toxic effects of blood, oxidative stress, recruitment of activated microglia/macrophages and neutrophils and excitotoxicity. Brain tissue is particulary vulnerable oxidative attack due to its rich content in polyunsaturated fatty acids which favors lipid peroxidation. Different from other tissues, brain presents only reduced amounts of antioxidant enzymes – catalase (CAT), glutation peroxidase (GPX) and superoxid dismutase ( SOD) and their activity decreases with age. It also contains elevated amounts of non-heme iron. The study of neuroprotection in ICH use as targets pathological processes like oxidative stress, inflammation, cerebral edema. In this context, the role for oxidative stress in and potential antioxidant therapies were analysed.