Andra Teodor, Laura Ghibu, Carmen Dorobăţ, D. Teodor, Codrina Bejan, V. Luca
Clinica de Boli Infecţioase – Iaşi
Abstract
OBJECTIF – To evaluated clinical and ethyological aspects, diagnosis and treatment possibilities at patients hospitalised with severe fungal infections in Clinic of Infectious Diseases – Iasi. MATERIAL AND METHODS – Retrospectiv study between 2004 – 2007 included all patients with severe fungal infection admitted in Clinic of Infectious Diseases. RESULTS – 29 patients (median age – 65 years). Risk factors for invasive fungal infection were: associated clinical entities (neurological pathologies – 14, renal failure – 6, diabetis – 4, cirrosis – 3, respiratory conditions – 2, pancitopeny – 2) and medical procedures (urinary catheter – 19, central intravenous catheter – 3, hemodialysis – 3). Fungal species were isolated from uroculture – 19, hemoculture – 5, culture of tracheal aspirate – 5.The most frequent specie was Candida albicans – 18 cases. In 4 cases of sepsis, Candida was associated with S. aureus. Antifungal testing identified resistance at Flucitosine (1 case) and intermediary susceptibility at Itraconasol (1 case). Fluconasol was preffered in therapy – 17 cases. In evolution 6 deces. CONCLUSIONS – Severe fungal infection has an increasing incidence in our hospital in the same time with increasing risk. We didn’t observe significant changes in ethiology and antifungal susceptibility.