O. Roşca, L. Negruţiu
UMF “V. Babeş” Timişoara, Spitalul de Boli Infecţioase şi Pneumoftiziologie “Dr. V. Babeş” Timişoara, Clinica I Boli Infecţioase
Abstract
The discovery of new antiretroviral therapy raised the life expectancy of HIV infected patients. The use of this in different combinations (HAART) determined some side effects, one of more important being the high cardiovascular risk. We present the cases of 2 HIV infected patients under HAART therapy. In both cases, there was an increase of total seric cholesterol, of triglycerides, of LDL-cholesterol and a decrease of HDL cholesterol. This biologic disturbances were accompanied by lower (the best expressed) and upper limbs lipoatrophy, facial lipoatrophy, and abdominal, pectoral and posterior cervical lipohipertrophy. One of these cases presented ecg disturbances (sinusal tahicardy, abnormalities of Q wave, ST subdenivelation). In the other case, there have been observed hypertensive attacks. The Doppler Ecography of the later patient showed a reduced diameter of the right carotid artery with an atheromatous deposit at this level. Concluding, the patients under HAART therapy have a higher risk for cardiovascular disturbances comparatively to the normal population. A rigorous monitoring of cardiovascular risk factors is necessary, accompanied by an adequate HAART therapy.