S. Iurian *, B. Neamţu *
* Dr. Sorin lurian, Prof univ. dr Bogdan Neamţu, Sef Clinică – Clinica de pediatrie Sibiu
Abstract
The lymphocyte Th2 plays a pivotal role in initiation and progression of allergic disease, including asthma. The concept of imbalance Th1/Th2 isn’t able to explain many experimental observations. Recently, many different T regulatory cells subsets have been described, including CD4+ T regulatory cells, CD8+ T regulatory cells and natural killer (NK) cells. Among them, CD4+ T regulatory cells consist of naturally occurring CD25+ T regulatory cells and, also, adaptive T regulatory cells that are further subdivided into T-regulatory cells type 1 and T-helper cell type 3 that mediate supression and could explain few mechanisms in asthma pathogenesis. At present, the chemokine expression during chronic inflammatory diseases is more understood as compare to previous years. Many data suggest that post-transcriptional regulation plays an important role in chemokine gene expression. Some recent data indicates that mechanisms controlling mRNA stability may be important in determining and maintaining the increased levels of chemokine gene expression. These pathways may be targets of novel anti-inflammatory strategies.