Ilinca Niculae *, Oana Coman *, Sorina Schiper *, Simona Georgescu *
* Dr. Ilinca Niculae, dr. Sarina Schiper, conf. dr. Simona Georgescu – Spitalul Clinic de dermatovenerice “Prof dr. Scarlat Longhin”, Centrul de Dermatovenerologie, BucureștiConf. dr. Oana Coman – Universitatea de Medicină și Farmacie ,,Carol Davila”, Facultatea de Medicină, București
Abstract
The establishment of a correlation between severity of atopic dermatitis and intracellular and extracellular varia tions of magnesium. The study was randomized on 120 patients with medium or severe atopic dermatitis and ages between 6 and 81 years. Each patient was clinically and paraclinically evaluated. The clinical parameters observed were pruritus, erythema and, eventually, vesiculous blisters. The paraclinical tests involved the assesement of plasmatic and erythocyte magnesium level in acute periods of disease and in the remission interval between acute periods. In the acute periods of atopic dermatitis, plasmatic levels of magnesium do not significantly vary between patients and control (0.84 ± 0.09 mmol/L versus 0.86 ± 0.08 mmol/L). The erythrocyte content of magnesium was significantly reduced in patients with atopic dermatitis (1.66 ± 0.14 fmmol/cell versus 1.78 ± 0.16 fmmol/cell in the control group). During the remission disease periods, there was not a significant difference in erythrocyte magnesium content between the group with atopic dermatitis and the control group. Measurements of the erythrocyte content of magnesium is an useful method for the identification of this cation deficit in patients with atopic dermatitis.