A. A. Tica *, V. Tica **, C. Georgescu *
* Disciplina de Farmacologie, Facultatea de Medicină, U.M.F. – Craiova
** Disciplina de Obstetrică și Ginecologie, Facultatea de Medicină, Universitatea din Constanța
Abstract
The phosphatidil inositol complex represents the main mechanism for intracellular signal, following membranal receptor activation. IP3 is the most important member of this group, but not the only one. IP3 induces mobilization of the calcium from internal stores, after coupling with its receptor (Ca2•-channel). This calcium will start different cellular processes. The interaction of IP₃ with the specific receptor is modulated by several mechanisms, like protein kinase A, protein kinase C, Ca2·-calmodulin kinase, pH, Mg2•, ATP and also by calciu or by the receptor itself. The biological role of the others phosphoinositols is still unknown. They have some affinity for the IP₃-receptor but there were identified some other receptors, specific for them, also with not well established significance.