E. D. Popescu *, Ruxandra Ionescu *
* Prof. Dr. E. D. Popescu, Conf. Dr. Ruxandra Ionescu – Clinica de Medicină lnternă și Reumatologie a Spitalului “Sf. Maria”, București
Abstract
Tegumentary topic therapy is used in treating dermatological and nondermatological diseases, in which the end points are either systhemic or local. Among topic therapy with systhemic end point can mention: estrogenic therapy in menopause disorders, nitrates therapy in coronary disorders and so on. In rheumatology, the tegumentary topic substances are classified in revulsive and active substances. The first one produce vasodilation and increase the local temperature, thus reliefing the pain. As for the second one (vehiculation of active substances) its action is foccussed on the inflammatory process of several causes and the behavior of superficial vessels. The steroid and non-steroid anti-inflammatory drugs can be administered topic tegumentary, being eficient in treating many rheumatic diseases such as: arthrosis, rheumatic poliarthritis, scapulohumeral periarthritis, bursitis, tendinitis. Among the advantages of this type of treatment it is worth mentioning protecting the digestive tract and eliminating the effects of the first hepatic passage. The tegumentary absorption of this drugs is influenced by factors which depend on the patient (age, condition of the skin) and on the drug {active substance and its vehicle, which can be water, alcohol or lipids). Among the topic non-steroid anti inflammatory drugs Fastum Gel (ketoprofen) has a good tegumentary penetrability.