Roxana Boacă *, D. Orășeanu **, E. Ciofu **, V. Cialâcu *, N. Ionescu *, Ș. Georgescu ***
* Prep. Dr. Roxana Boacă, șef Lucr. V. Cialâcu, Prof. Dr. N. Ionescu, Departamentul de Biologie Celulară și Histologie, U.M.F. “Carol Davila” București
** Conf. Dr. D. Orășeanu, Prof. Dr. E. Ciofu, Clinica de Pediatrie, Spitalul Clinic Central de Copii, București
*** Prof. Dr. Ș. Georgescu, Clinica de Imagistică Medicală, Spitalul Clinic Fundeni, București
Abstract
Nephrotic syndrome can be divided etiologically into: primary (idiopathic) or secundary (included in systemic disorders). We will exemplify by presenting two cases of the Pediatrics Clinic of the Central Children Hospital-Bucharest. In the first case nephrotic syndrome is included in the context of juvenile rheumatoid arthritis treated by anti-inflamatory drugs and gold salts. The second one is a primary nephrotic syndrome. We briefly present: the history of the disease, the clinical and biological status of the patientes starting with the hospital admission, during treatment and evolution up to now. In both cases the nephrotic syndrome was cortisone-resistent. Therefore, bioptic Kidney punction was needed for establishing a valid anatomopathological diagnosis. The samples were prepared for examination with the light microscope, transmission electron microscope and in the EDX (Energy Dispersive X-ray) analysis mode. The results led us to the diagnosis of membranous glomerulonephritis for the first case and of membrano-proliferative glomerulonephritis for the second case. Both patientes reacted favourably at alternative administration of Prednisone and Cyclophosphamide. Our paper underlines the importance of modern investigative techniques in obtaining a certain diagnosis and also in choosing the best course of treatment to ensure an adequate prognosis.