A. Al-Baidani *, D. Bălălău **, Rodica Alexandrescu ***, Mihaela Ilie **, Daniela Luiza Baconi **, Mihaela Gheorghe **
* Abdul Al-Baidani, farmacist specialist, doctorand al UMF “Carol Davila”, București, asistent în
cadrul Hodeidah University, Hodeidah, Republic of Yemen
** Prof. dr. farm. Dan Bălălău, dr. chim. Mihaela Ilie, conf dr. farm. Daniela Luiza Baconi,
doctorand farm. Mihaela Gheorghe – Disciplina Toxicologie, Facultatea de Farmacie, UMF “Carol Davila”, București
*** Dr. primar Rodica Alexandrescu – Centrul de Cercetări Științifice Medico – Militare, București
Abstract
Poly-addiction is a problem that needs a special analysis because such cases are more often found at the emergency hospitals. Most of such cases are addicts with one opioid and one or more other substances. The paper is aimed at analysing the toxic effects resulting from co-administration of codeine together with gluthetimide and methadone together with alprazolam in a subacute experiment performed on Wistar rats, focus ing on the hystopathologic analysis of brain, hepatic and renal tissue. Results indicate that while co-administration of codeine and gluthetimide, even resulting in cerebral oedema, do not result in visible toxic effects, co-administration of metha done and alprazolam resulted in a 40% mortality among the animals and in toxic effects on the cerebral hepatic and renal tissue, thus underlying the risk implied by the consumption of drugs in such combinations.