Ana Maria Daviţoiu 1, 2, Bărcănescu Ş. 3, Negulescu V.Al. 1, Avram Oana 1, 4, Voicu V.A. 5, 1, Macovei R. 1, 4, Tudosie M. 6, 1, Caragea Genica 6, Forje Mărgărita 6, Mladin C. 7, Fragkos A. 8, 9, Ardelean Luminiţa 1, Bumbea Viorica 4
1 University of Medicine and Pharmacy „Carol Davila” Bucharest
2 Victor Gomoiu Hospital Bucharest
3 Institute of Mathematics of the Romanian Academy
4 Clinical Emergency Hospital Bucharest
5 Romanian Academy
6 Army Center for Medical Research
7 Mecro System Bucharest, Romania
8 Fragkos Medical Center Bucharest
9 Mediterraneo Hospital Athens, Greece
Abstract
Selenium is an essential element of life. In humans, selenium is a cofactor of antioxidant enzymes, such as glutathione peroxidase and certain forms of tioredoxin – reductase. Selenium may inhibit Hashimoto’s disease (in which thyroid cells are attacked by autoantibody). Patients with chronic renal failure are usually subjected to three weekly dialysis procedures. Since selenium removal is done only during the dialysis procedure, it is important to study it to determine the risk of high level of selenium in blood. For determination of selenium concentrations, authors used a Varian atomic absorption spectrometer with graphite tube atomizer, GF-AAS. We have performed a comparative study concerning selenium concentrations in blood determined on subjects in a control group versus blood selenium concentrations in subjects belonging to a group of patients undergoing dialysis procedure. In order to highlight the selenium removal dynamics in dialysate fluid, samples were collected during dialysis procedure at predetermined intervals. Statistical analysis concerning the differences between the averages selenemia in the patients group versus control group, and the Lagrange polynomial interpolation ruling the variation of selenium level in the dialysate fluid, in order to establish eliminations equation of selenium in chronic renal disease patients during the dialysis procedure, are presented in this paper.