Rus Natalia Niculina, Bocșan Ioana Corina, Buzoianu Anca Dana
Department of Clinical Pharmacology, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
Abstract
The aim of this study is to assess the pregabalin effects in different doses, single administration, on animal model of acute nociceptive pain. Material and method. We used 50 males Wistar Bratislava rats randomized in 5 groups: a control group treated with saline solution, the 2nd and 3rd groups injected with metamizole 50 mg/kg, respectively tramadol 10 mg/kg and 2 experimental groups treated with different doses of pregabalin 15 mg/kg and 30 mg/kg. The evaluation of pain perception was performed before injection (baseline) and after drug administration (ip 0.5 ml/100g) using 3 methods: paw pressure test, hot plate test and tail flick test. The obtained data were statistically analyzed, considering significance at p<0.05. Results. PGB (30mg/kg) increases the pain threshold after 1 hour (tail flick test), is maximal at 2 and 4 hours (tail flick and hot plate tests) and is maintained up to 24 hours (paw pressure test). PGB (15mg/kg) increases also the pain level after 1 hour (tail flick test), but is inconstant at 2 hours, increases again at 4 hours (hot plate test) and is maintained at 24 hours after administration (tail flick test). Conclusions. PGB(30 mg/kg) in single administration, has an analgesic effect in nociceptive pain in all 3 used tests, compared both with control and metamizole or tramadol. PGB 15 mg/kg has an inconstant and less intense analgesic effect. PGB’s analgesic effect in acute pain is dose dependent.