Cristina Popescu *, G. Popescu *
* Dr. Cristina Popescu, Dr. Gabriel Popescu – Asistenți universitari, lnstitutul de boli infecțioase Prof. dr. Matei Balș, Clinica I Colentina, UMF “Carol Davila”, București
Abstract
Systemic infection is a clinically defined entity of altered organ perfusion resulting from a systemic inflammatory response of the organism. Current estimates indicate that the incidence and mortality are increasing, most likely because of the increased use of immunosupressive therapies and invasive devices. A Consensus Conference has defined a set of Systemic inflammatory syndromes intended to reflect hierarchical degrees of physiologic response: systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock and MODS. The major implications of this concept are: a good inclusion of patients with sepsis, a better understanding of the epidemiology of sepsis and a betterment of the therapy. The use of gravity scoring in patient with sepsis has been improved. Knaus recently published a paper describing a new mortality prediction model for the clinical evaluation of new drugs for sepsis. APACHE Ill was shown to have the highest predictive value.