Carmen Ardeleanu *, Sabina Zurac **, Alexandra Vrabie **, Luciana Lavric **, Gianina Micu **, Eliza Gramada **, Anca Zaharia **, R. Andrei **, Florica Stăniceanu *, A. Streinu-Cercel ***
* Conf. Dr. Carmen Ardeleanu, prof. dr. Fiorica Stifoiceanu • Departamentul de Anatomie Patologică, lnstitutul Victor Babeș
** Sabina Zurac, Alexandra Vrabie, Luciana Laurie, Gianina Micu, Eliza Gramada, Anca Zaharia, Răzvan Andrei – Serviciul de Anatomie Patologică, Spitalul Clinic Colentina
*** Prof dr. Adrian Streinu-Cercel – Clinica de Boli lnfecțioase, Institutul de Boli Infecțioase “Matei Balș”
Abstract
Hepatitis D virus (HOV) chronic hepatitis (which is frequent in Romania) shows no specific histopathologic lesions comparing with other viral etiologies. We studied 58 cases of HBV-HDV chronic hepatitis; the results were compared with a group of 355 cases of HBV chronic hepatitis; a statistical analysis was performed – CHITEST, FISCHER and STUDENT tests were used with a level of statistical significance (P) of 0.05. In HBV-HDV chronic hepatitis, comparing with HBV chronic hepatitis there were significant more important lobu lar inflammation (P=0.004), interface hepatitis (P=0,002), spotty necrosis (P=0,005), steatosis (P=0.025), Kupffer cells hyperplasia (P=0.007), necro-inflammatory activity (P=2,25428×10-07) and fibrosis (P=9,83716×10-07); the portal inflammatory infiltrate and ballooning degeneration were more prominent in HBV-HDV chronic hepatitis but P values were outside of the confidence range (P=0.052 and P=0.057). We conclude that HBV-HDV chronic hepatitis have a more aggressive histopathologic appearance – higher necro-inflammatory activity (with an elevation of all histo pathologic parameters of necrosis and inflammation except confluent necrosis), higher hepatocytic degeneration and higher fibrosis.