Melinda Kolcsar *, Ildiko Vicsi **
* Melinda Kolcsar – asistent universitar farmacolog, medic specialist medicină internă și endocrinologie, UMF Tg. Mureș, Facultatea de Farmacie – Disciplina de Farmacologie
** Ildiko Vicsi – medic rezident endocrinolog, Clinica de Endocrinologie, Tg. Mureș
Abstract
Angiotensin II (AT II) results through angiotensin converting enyzme effect on angiotensin I and through chymase way. The resulted circulatory AT II has vaso constrictory and sodium retention effects, and the tissue AT II effects adds to it or differ from them. The active tissue AT II exerts its effects via different types of angio tensin receptors: AT1-R, AT2-R, AT3-R and AT4-R. The physiological role of AT II is realised through AT1-R, and the AT2-R is important in fetal life, being involved in the brain development, neuronal differentiation, migration and apoptosis. Altered AT2-R expression was demonstrated in neurodegenerative disorders.