V. Dumitraşcu *, Anca Alexandra Matusz **, Daniela Ştefania Grecu *** , Daliborca Cristina Vlad ****
* Conf. dr. V. Dumitrașcu, Departamentul de Farmacologie, Universitatea de Medicină și Farmacie
“Victor Babeș”, Timșoara
** Dr. Anca Alexandra Matusz, medic primar, doctor în științe medicale, Cabinet Medicina Familiei, Timișoara
*** Asist. univ. dr. Daniela Ștefania Grecu, Departamentul de Biochimie, Universitatea de Medicină și Farmacie “Victor Babeș”, Timșoara
**** Dr. Daliborca Cristina Vlad, doctorand farmacologie, Universitatea de Medicină și Farmacie Victor Babeș, Timșoara
Abstract
Classic generation antiepileptics have shortcomings such as suboptimal response rates, significant adverse effects, several drug interactions, and a narrow therapeutic index. The newer generation, including topiramate, have better therapeutic profiles, low interaction potential, and significantly less enzyme inducing properties.This study presents the concrete case study of a 6 years old child, who eliminated a phosphatic renal stone after long-term topiramate anticonvulsant therapy. Some other particular adverse events are pointed out: weight decrease, acute myopia, osteomalacia and leucopenia. In correlation with several important side-effects, this review highlights the particular pharmacokinetics of topi ramate in pediatric patients.