B. A. Hagiu 1, V. Tura 2, Doina Mahaila 3, M. Fantanaru 4, O. C. Mungiu 5
1 Faculty of Physical Education and Sport, “Al. I. Cuza” University, Iaşi
2 Faculty of Physics, “Al. I. Cuza” University, Iaşi
3 Children’s Clinical Emergency Hospital “Sf. Maria”, Iaşi
4 Faculty of Veterinary Medicine, “Ion Ionescu de la Brad” University, Iaşi
5 Department of Pharmacology-Algesiology, Center for the Study and Th erapy of Pain, “Gr. T. Popa” University of Medicine and Pharmacy, Iaşi
Abstract
Our previous studies revealed the ability of composite materials based on Ag nanoparticles to induce hair follicle regeneration. As a step forward in this research, the present study investigates the biocompatibility of composite materials consisting of polyurethane-urea nanofi bers functionalized with silver nanoparticles by subcutaneous implantation in rabbits. In the same time, we recorded the influence of these materials on hair follicles. Macroscopically we noticed acceleration of surgical wound cicatrisation and of hair growth in the area located above the composite material implant. Microscopic analysis revealed that the infl ammatory response produced by implantation was minimal, the nanofi brilar matrix serving as support for the multiplying of young fi broblasts, and above it the hair follicles proliferate in the hypodermis and dermis. The biological eff ects suggest that these composite materials could be used as dressings for teguments covered with hair.