Daviţoiu Ana Maria 1,2, Truţă Elena 3, Negulescu Cristina 4, Constantin Laura 3, Stoica Alexandra 3, Pleşca Anca Doina 1,2
1 Clinical Emergency Children’s Hospital “Victor Gomoiu”, Bucharest, Romania
2 University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
3 Clinical Emergency Hospital, Bucharest, Romania
4 National Institute of Infectious Diseases “Prof. Dr. Matei Balș”, Bucharest, Romania
Abstract
Deficit Hyperactivity Disorder (ADHD) is considered to be a neurodevelopment condition with a worldwide prevalence between 3-10 % in children1 with symptoms that could continue into adolescence for 50-80% of cases and into adulthood for as many as 30 – 50 % of cases. The purpose of the research was to evaluate the efficacy and safety of pharmacological treatment in attention deficit hyperactivity children. A retrospective clinical research in 73 patients was designed and carried out at “Victor Gomoiu” Clinical Pediatric Hospital. The data was obtained from patients medical records. The study duration was 15 months from Jan 2013 to March 2014. The medical treatment was analysed: type of drugs given, dosage, pharmaceutical formulation, length of treatment. We also analysed the types of non-medical treatments associated: psychological therapy, logopedic therapy, occupational and cognitive stimulation therapy, other types of therapy. Monthly monitoring and identification of adverse events was done for each patient by analysing the type of medication given, adverse event onset, severity, dose optimization, withdrawal from treatment or change of medication. Data was stratified for three age groups: preschool children (< 7years old), 12 to 18 – year-olds and 7 to 11 – year- olds. Combined therapy (both medical and psychological) gave results but without being able to determine the measure in which either the psychological, pharmacological or combined treatment have influenced the end result. Early detection and management of side effects (dose optimization, change of medication, drug combinations that diminish or even eliminate the side effects, treatment interruption) improve compliance and adherence towards the given medical treatment but also improve the quality of life.