D. Vasile 1, O. Vasiliu 2, Mihaela Vasile 3, Oana Crețu 3
1 medic primar psihiatru, doctor în știinte medicate, Spitalul Clinic de Urgență Militar Central “Dr. Carol Davila” București
2 medic specialist psihiatru, Spitalul Clinic de Urgență Militar Central “Dr. Carol Davila” București
3 medic rezident psihiatru, Spitalul Clinic de Urgență Militar Central “Dr. Carol Davila” București
Abstract
The ethiology of mood disorders is not yet completely known and the high rates of conventional treatment resistant cases is consistent with this observation. The involvement of glutamate and NMDA receptors in the pathogenesis of mood disorders is based on consistent, yet not complete, experimental data. The preclinical experiments (behavioural animal models of depression) as well as pharmacological clinical data from trials with ketamine or lamotrigine support the glutamate hypothesis. New therape utic perspectives could result from data analysis that support the role of glutamate in mood disorders.