Irina M. Jaba *, B. Tamba *, Liliana Tarlău *, O. C. Mungiu *
* Irina M. Jaba, Bogdan Tamba, Liliana Tarţău – asistenti universitari, prof univ. Ostin C. Mungiu – Disciplina de Farmacologie-Toxicologie-Algeziologie, Universitatea de Medicină şi Farmacie ,,G T Popa” Iaşi
Abstract
Pain management is one of the toughest challenges that the medical community faces. Due to the numerous adverse effects of the existing narcotic analgesics, many patients remain untreated or without any treatment at all. The main inconveniences of the current analgesics are the effects on the Central Nervous System and the gastrointestinal effects. Therefore, the goal of all new classes of analgesics under research is to increase the selectivity on the situs of action and to minimize all unwanted effects. There are currently two main research areas: the oriented design of exogene opioids agonists and that of endogene opioid peptides. One of the most used method in experimental and theoretical studies is the computer aided drug design. The new molecular and genetic investigation methods, associated with the significant advance in computer technology, allow for a new approach regarding the research of new analgesic compounds.