Gabriela Cioca 1, Liviu Safta 2, Dana Goşa 2
1 Discipline Pharmacology, “Victor Papilian” Faculty of Medicine, Sibiu,
2 Department of Pharmacology, “Iuliu Haţieganu” University of Medicine and Pharmacology, Cluj-Napoca
Abstract
Angiotensin II (ATII) causes through the central nervous mechanism certain cardiovascular disorders. Th e participation of a central nervous component in the genesis of cardiac arrhythmia caused by Angiotensin is stated. Th e present paper describes the action exerted by ATII on the cardiac rhythm, after intracerebroventricular administration (icv) in rats anesthetized with ethylic urethane. Th e disorders of the cardiac rhythm induced by the ATII may be prevented or attenuated by blocking the AT1 receptors with and adequate antagonist, administered through icv.