Cristina Anca Sârbulescu *, Rodica Alexandrescu *, Josephina Neagu-Slobozeanu *, Cristiana Cosmescu *, L. Miclea ***, A. Căsăndroiu *, Gh. Țarălungă ***
* Cristina Anca Sârbulesuc, Rodica Alexandrescu, Josephina Neagu-Slobozeanu, Cristiana Cosmescu, Adrian Căsăndroiu, Centrul de Cerceitiri Științifice Medico-Militare, București
** Universitatea de Medicină și Farmacie “Ovidius” Constanța
*** Liviu Miclea GheorgheȚarălungă, Universitatea de Medicină și Farmacie “Carol Davila” București, Spitalul de Copii “Grigore Alexandrescu”
Abstract
The study of the OP delayed neurotoxicity and its treatment was performed using the pinacol yl methylphosphonofluor idate (GD). The objective was represented by the experimental emphasis of the GD delayed neurotoxicity and the test of a treatment method. Method: the experimental study was performed using four groups of Wistar male rats, the complete method will be presented in the paper. Results: the GD delayed neurotoxicity was e mphasized 7 days after the poisoning by the dystrophic and degenerative lesions at the Purkinje cells and the sciatic popliteu nerve level (first study group); the preventive and curative antidotal treatment didn’t antagonize the GD delayed neurotoxicity 14 days after the poisoning (second study group}; the curative treatment using piracetamum determined the remission of the nervous dystrophic and degenerative lesions (third study group). Conclusions: the GD delayed neurotoxicity was experimentally emphasized by the nervous dystrophic and degenerative lesions, without spontaneous remission, partially antagonized by the antidotal treatment. The piracetamum administration (a nootropic compound involved in the cerebral ATP level increasing) has experimental antagonized the GD delayed neurotoxicity.